Isothiocyanates are some of the most important plant compounds you can get in your diet. In this video I make the most comprehensive case for them that has ever been made. Short attention span? Skip to your favorite topic by clicking one of the time points below. Full timeline below the fold…

Key sections:
00:01:14 – Cancer and mortality
00:19:04 – Aging
00:26:30 – Brain and behavior
00:38:06 – Final recap
00:40:27 – Dose

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Full timeline:
00:00:34 – Introduction of sulforaphane, a major focus of the video.
00:01:14 – Cruciferous vegetable consumption and reductions in all-cause mortality.
00:02:12 – Prostate cancer risk.
00:02:23 – Bladder cancer risk.
00:02:34 – Lung cancer in smokers risk.
00:02:48 – Breast cancer risk.
00:03:13 – Hypothetical: what if you already have cancer? (interventional)
00:03:35 – Plausible mechanism driving the cancer and mortality associative data.
00:04:38 – Sulforaphane and cancer.
00:05:32 – Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
00:06:06 – Effect of direct supplementation of sulforaphane in prostate cancer patients.
00:07:09 – Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
00:08:32 – Inhibition of breast cancer stem cells.
00:08:53 – History lesson: brassicas were established as having health properties even in ancient Rome.
00:09:16 – Sulforaphane’s ability to enhance carcinogen excretion (benzene, acrolein).
00:09:51 – NRF2 as a genetic switch via antioxidant response elements.
00:10:10 – How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
00:10:34 – Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
00:11:20 – Broccoli sprout drink increases benzene excretion by 61%.
00:13:31 – Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
00:15:45 – Cruciferous vegetable consumption and heart disease mortality.
00:16:55 – Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
00:19:04 – Beginning of aging section.
00:19:21 – Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
00:20:34 – Importance of low inflammation for longevity.
00:22:05 – Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
00:23:40 – Mid-video recap: cancer, aging sections
00:24:14 – Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
00:25:18 – Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
00:26:30 – Beginning of brain and behavior section.
00:27:18 – Effect of broccoli sprout extract on autism.
00:27:48 – Effect of glucoraphanin on schizophrenia.
00:28:17 – Start of depression discussion (plausible mechanism and studies).
00:31:21 – Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
00:32:00 – Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
00:33:01 – Beginning of neurodegeneration section.
00:33:30 – Sulforaphane and Alzheimer’s disease.
00:33:44 – Sulforaphane and Parkinson’s disease.
00:33:51 – Sulforaphane and Hungtington’s disease.
00:34:13 – Sulforaphane increases heat shock proteins.
00:34:43 – Beginning of traumatic brain injury section.
00:35:01 – Sulforaphane injected immediately after TBI improves memory (mouse study).
00:35:55 – Sulforaphane and neuronal plasticity.
00:36:32 – Sulforaphane improves learning in model of type II diabetes in mice.
00:37:19 – Sulforaphane and duchenne muscular dystrophy.
00:37:44 – Myostatin inhibition in muscle satellite cells (in vitro).
00:38:06 – Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
00:40:27 – Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
00:41:01 – Anecdotes on sprouting at home.
00:43:14 – On cooking temperatures and sulforaphane activity.
00:43:45 – Gut bacteria conversion of sulforaphane from glucoraphanin.
00:44:24 – Supplements work better when combined with active myrosinase from vegetables.
00:44:56 – Cooking techniques and cruciferous vegetables.
00:46:06 – Isothiocyanates as goitrogens.

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46 thoughts on “Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More”

  1. it works for anti aging .im 56 years old,i drank a 55 gallon drum of it last night,when i woke up today i was about 6 months old.im bald,i have no teeth and i have been drooling on myself all day.but im so happy,no worries and no taxes and no wife.

  2. What do you do if you have IBS and any cruciferous vegetable causes extreme gastrointestinal discomfort and makes you shit yourself, causing a Pavlovian response of discomfort even if you don't eat it?

  3. Rhonda, I'm here a little late from one of your recent videos. I know you always recommend getting nutrients through natural sources but I get a little overwhelmed with all the volume of cruciferous vegetables. I'm already doing your first version Kale smoothie every day, would you suggest supplementing with super sprout broccoli sprout powder? How much per day?

  4. Cruciferous vegetable intake is just a leading indicator of an overall healthier lifestyle, or someone who attempts to eat healthy.

    I highly doubt its any particular compound in the vegetables that cause the lower lung cancer rate. We already know that Americans had much higher rates of lung cancer with a lower population of smokers compared to the Japanese.

    I'd bet eating a highly inflammatory and insulinogenic diet is what increases cancer risk, and anything that replaces glucose/fructose and omega 6 fatty acids will reduce the risk.

  5. Questions. . . For the cruciferous family (brassica) in p53 precursors. Does it matter to feminize them fully using banana and the predominant stage in enigma? They are bisexual, does it cause any hermafridation if an indoor of 1,ooo Watt bulb @ 42" is displaced? What are the certainties of no hermi'ing the bulb(s). Does it even matter? Just curious. . . Can present a 453,000 square foot indoor grow using LED for Bloom and vegetative states, with sources of either hydroponics or regular, but thinking of cruciferous seedlings as the business model. Any advice?

  6. Dosage of 40 to 60mg? When I look for Sulforaphane capsules, they typically contain about 400mcg. Where are people finding supplements that contain 40mg+ of sulforaphane?

  7. Without stating the study and or studies it just sounds like many "other" experts, but not credible information, specific studies or reports are needed for all the of the
    time spent at this video.

  8. Ok I am done for this week from this much information! Basically (daily take 50g of Brussels Sprouts extract, Omega-3s from krill oil, drink green tea and watch your videos) and live 110 years

  9. Great Video Rhonda! We truly appreciate the work your doing, and more importantly making the information available for free! You are amazing. I have been using Spout Living's FD Sprout Mix- Broccoli & Kale product from my store in Canada.
    This product is a freeze dried Broccoli and Kale Sprouts ground into a powder for easy use. I use them in shakes and smoothies.
    Check out the link if you interested!

    https://www.optimizenutrition.ca/vitamins-health-supplements/sprout-living-fd-sprout-mix-113-broccoli-kale/

  10. when i drink two cups a day of broccoli soup with tumeric and black pepper my PSA (I have prostate malignancy, very small, so we watch it) goes down 20% in 5 months. When I go off of it, it goes back up. I've tested this 3 times and it is always the same. Broccoli with tumeric and black pepper (read The Anti-Cancer Diet book and decide for yourselves!!) lowers PSA which, if you already have prostate cancer DOES indicate cancer increase or decrease, (from all that I've read.) So, that's it. judge for yourself. the worst that can happen is you eat broccoli. beats nourishing cancer.

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